Puzanova O.G. Nonsteroidal anti-inflammatory drugs-associated gastroduodenal injuries in osteoarthritic patients: peculiarities of diagnosis, prophylaxis and treatment. – Manuscript.
Thesis for a scientific degree of candidate of medical sciences by speciality 14.01.02 – internal diseases.– National Bohomolets medical university, Kyiv, 2001.
The thesis is devoted to the problem of improving both quality of diagnosis and efficacy of prophylaxis and treatment of NSAID-gastroduоdenopathies in osteoarthritic patients. Taking into account both NSAID-therapy duration and its methods used, the risk-factors presented, patients’ Helicobacter pylori-status and their adrenal glands’cortisol-productive function, it has been described the frequency of the revealed erosive-and-ulcerous lesions, as well as their clinical and endoscopic peculiarities. The efficacy of ulcers monotherapy with misoprostol has been evaluated.
Key words: osteoarthritis, nonsteroidal anti-inflammatory drugs (NSAIDs), gastroduodenopathy, diagnosis, prophylaxis, treatment, Helicobacter pylori, cortisol.
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