SUMMARY
Dzhelomanova S.A. Autoimmune mechanisms of fetus retardation (prognosis, prevention and treatment). – Manuscript.
The dissertation for the degree of a candidate of sciences (medicine) speciality 14.01.01 – obstetrics and gynecology.
The dissertation deals with the problems of increasing the efficacy of the current treatment and prophylaxis methods in pregnant women with fetus retardation (FR) for the purpose of decreasing perinatal pathology.
A retro- and prospective analysis of somatic, and obstetric and gynecologic anamnesis of pregnant women with fetus retardation has been made. The factors contributing to the development of FR have been singled out and grounded. A program of prognosing this complication of pregnancy has been developed as well. Clinical, immunologic, hemostasiologic features of the course of pregnancy and labour, the condition of the fetus and new-borns of women with FR.
On the basis of an over-all study of systemic changes in the body of mother and the fetoplacental complex it has been proved that the autoimmune process plays an essencial part in FR development. For the first time the immunologic markers threatening the development of FR have been determined and the dependence of a hypotrophy severity degree on the level of antiphospholipid antibodies and activity of a pathologic process. Has been studied. An algorhythm of studying the pregnant women from the FR development high risk group has been developed.
A complex of preventive and therapeutic measures which includes rheo- and immunocorrection, efferent methods and allows to diminish most complications of pregnancy, perinatal sick- and death-rate has been developed and put into practice.
Key words: fetus retardation, autoimmune process, pregnanсу.
ПЕРЕЛІК УМОВНИХ ПОЗНАЧЕНЬ, СКОРОЧЕНЬ ТА ТЕРМІНІВ
АКЛА – антикардіоліпінові антитіла
АМГФ – альфа-2-мікроглобулін фертильності
АФЛА – антифосфоліпідні антитіла
АЧТЧ – активований частковий тромбопластиновий час
ВА – вовчковий антикоагулянт
ДВЗ – дисеміноване внутрішньосудинне згортання
КТГ – кардіотографія
П – прогестерон
ПАМГ – плацентарний альфа-1-мікроглобулін
ПДФ – продукти деградації фібриногену
ПІ – протромбіновий індекс
ПЛ – плацентарний лактоген
ПМК – порушення мозкового кровоплину
РП – ретардація плода
СДР – синдром дихальних розладів
ТБГ – трофобластичний бета-хоріальний гонадотропін
УЗД – ультразвукове дослідження
ФНП- α – фактор некрозу пухлин α
Е3 – естріол
В2-ГП-1 – бета-2-глікопротеїн-1
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